Schedules of Controlled Substances: Temporary Placement of Mitragynine Pseudoindoxyl, MGM-15, and MGM-16 in Schedule I
The DEA is temporarily placing mitragynine pseudoindoxyl, MGM-15, and MGM-16 into Schedule I, making them illegal to possess, handle, or dispense.
Aforeworn detected this change in the Pharmacy & Controlled Substances space on August 24, 2026 and published this briefing so affected operators are forewarned rather than caught off guard. It is rated Critical. All pharmacies, including independent, retail chain, compounding, and long-term-care pharmacies, that may encounter these substances. should confirm how it applies to their specific situation before acting. There is a time constraint attached: Effective immediately upon publication in the Federal Register (temporary scheduling is immediate).. Acting after that point can mean penalties, a lapsed licence, or lost eligibility — exactly the kind of surprise Aforeworn exists to prevent. Aforeworn monitors Pharmacy & Controlled Substances continuously and turns every detected change into a plain-English briefing like this one, so you always know first. Forewarned is forearmed.
What changed
Three substances (mitragynine pseudoindoxyl, MGM-15, MGM-16) are now temporarily Schedule I controlled substances, subject to full regulatory controls.
Who it affects
All pharmacies, including independent, retail chain, compounding, and long-term-care pharmacies, that may encounter these substances.
What you must do
Immediately cease any handling, dispensing, or possession of these substances; review inventory and supply chains for any presence; ensure staff are aware of the new scheduling.
Deadline
Effective immediately upon publication in the Federal Register (temporary scheduling is immediate).
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